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Sunday brings the initial Wear-Tyne derby since 2024, but who will emerge victorious – the Black Cats or Newcastle?
"During the bulk of last season, no one would have predicted the Wearside club getting promoted and being competitive with Eddie Howe's Newcastle, much less being above them in the table," remarked pundit Chris Sutton.
"The situation is very different now, and the way they play leads me to believe they've got a genuine opportunity."
The analyst is providing forecasts for all 380 Premier League games this campaign, against artificial intelligence, fans and a variety of guests.
For week 16, he is challenged by England Gaming star Daniel 'Stingray' Ray.
Ray is competing for honours for the eLions – the Football Association's formal esports team – at the football simulation European esports championship finals tournament, which is being held at Twickenham Stadium on Saturday.
You can watch Uefa's YouTube, IG Live and short-form video channels, as well as EA Sports FC Twitch and YouTube and England's Twitch.
Are you in alignment with their predictions? You can make your own predictions below.
The most popular scoreline picked for each game is displayed on the scoreboards at the bottom of this page.
A correct result (picking a win, draw or defeat) is worth 10 points. The exact score earns 40 points.
Ray, who also plays his club side and the Premier League champions as well as England, is competing for the first time at the eEuros finals after getting through the qualifying.
Eight players will play for their countries at the finals in a knockout format, vying for a substantial cash prize and a coveted spot in the FC Pro World Championship Play-Ins, with the Danish representative Anders Vejrgang defending the title he won last year.
"I am feeling really good for it," Ray remarked. "I've got a really good coach with me and practice has been going well.
"It is invariably an honour to play for your country. Naturally when you are younger, you dream about doing it as an professional footballer, but when you pursue a career in this profession and there is an opportunity to represent England, putting the shirt on is something unique.
"I overcame Vejrgang 9-4 in qualifying to get here. I've played against him throughout the year just in practice, and in other tournaments before - but I'd not previously defeated him in a tournament before.
"In my opinion he is the best player in the world so beating him in a tournament like this just gives you a massive injection of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The Blues were outstanding against the Gunners at the end of November, when they got a draw after being reduced to 10 men, and I was thinking this is it, they could possibly be title contenders.
In the matches following, however, they were beaten physically by Leeds, looked lethargic against Bournemouth and this week got defeated by Atalanta in the Champions League.
So manager Enzo Maresca really needs a win here to get back on track, but it won't be easy because the Toffees are such a threatening team.
Kiernan Dewsbury-Hall and Iliman Ndiaye are playing at the top of their game and they have got a bit of a positive run at the moment.
On form you would probably back the visitors, while the most logical prediction would likely be a draw, but I am not going to be sensible.
Chelsea haven't given me any compelling evidence to back them recently, but I just have a gut instinct Chelsea will win this match because they are at home and they are overdue a victory.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I'm attending this game and it will be fascinating to see what we get from the Reds.
I am really pleased for Reds boss Arne Slot to get such a crucial result at Inter Milan on Tuesday following all the discussion with Mohamed Salah this week.
Slot shouldn't need to put up with that distraction. I know Salah has been a great for Liverpool but at its core Slot just wants to win games and there is nothing personal in his team selection.
They changed their shape against Inter and went with a midfield diamond and two up top.
The media is going to be talking about whether Salah is selected for this game, but the only way he is going to be brought back into the fold is if he apologises.
Slot's attention will be on winning this game, but it is a difficult fixture.
You could argue it is the same for most teams but I find Brighton so hard to predict. I always feel they have got a goal in them, but they are defensively susceptible too.
The Merseysiders need to get back to stringing wins together, but I am not sure how much their exertions at the San Siro will have affected their stamina.
I've selected a couple of Brighton players in my Fantasy Premier League side, so they will almost certainly blank - but I do fancy get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
The Black Cats have had the opportunity to rest while Newcastle had to exert themselves against Bayer Leverkusen on Wednesday, only to let their lead slip away late on.
With the exception of their brilliant performance against Everton a couple of weeks ago, Newcastle's away form has been poor, particularly straight after they've played in the Champions League.
It is anticipated that that pattern to continue on Sunday, and their lack of freshness is likely to be a significant issue in how this game goes because of Sunderland's energetic style.
We saw how unwavering Regis le Bris's side are. They bullied the Gunners, and it was a joy to watch.
Commentators talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been excellent, but Noah Sadiki, who plays in midfield with him, has also been one of the best acquisitions and deserves some attention too.
I am expecting this being the best game|most exciting fixture